![]() ![]() Chromium is also present in many multivitamin/mineral supplements, and there are also specific chromium picolinate (CrP) supplements that contain 200–600 μg chromium per tablet ( 10). Trivalent chromium is found in a wide range of foods, including egg yolks, whole-grain products, high-bran breakfast cereals, coffee, nuts, green beans, broccoli, meat, brewer’s yeast, and some brands of wine and beer ( 8, 9). Chromium is now routinely added to TPN solutions ( 5). Other studies ( 4, 5) of the beneficial effects of chromium in patients receiving TPN have also been documented in the scientific literature. In the following 2 weeks, signs and symptoms of diabetes were ameliorated, with markedly improved glycemic status and greatly reduced insulin requirements (exogenous insulin requirements decreased from 45 units/day to none). Based on previous animal studies and preliminary human studies, the patient was given supplemental chromium. A patient receiving total parenteral nutrition (TPN) developed severe signs of diabetes, including weight loss and hyperglycemia that was refractory to increasing insulin dosing ( 3). ![]() Interest regarding chromium administration in patients with diabetes was kindled by the observation in the 1970s that it truly was an essential nutrient required for normal carbohydrate metabolism. This factor was eventually suggested to be a biologically active form of trivalent chromium that could substantially lower plasma glucose levels in diabetic mice ( 2). The interest in chromium as a nutritional enhancement to glucose metabolism can be traced back to the 1950s, when it was suggested that brewer’s yeast contained a glucose tolerance factor (GTF) that prevented diabetes in experimental animals ( 1). ![]()
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